In the past, urea manufacturing processes sometimes resulted in fertilizers with elevated biuret concentrations. In high concentrations, biuret interferes with internal N metabolism  and hinders protein formation in plants. Biuret is degraded by many soil microorganisms, but the rate is relatively slow. Modern urea manufacturing typically results in biuret concentrations less than 1.0 to 1.3%, which does not pose problems for most uses. There are some plant species that appear to be especially sensitive to biuret, so "low-biuret" urea should be used for foliar application in these situations.