The CO2 compressor is important equipment in a fertilizer factory, it supplies compressed CO2 gas into the reactor combined with liquid ammonia to form Urea. At Ca Mau Fertilizer Plant, from the beginning, when this equipment was put into operation, there were many problems, especially corrosion/erosion of labyrinth seals, high vibration, and compressor reverse rotation. With internal resources, we have collected, evaluated, identified the causes, and proposed solutions to thoroughly overcome these issues. Within the scope of this Technical Paper, we want to share the implementation process and the results brought after improving the system.