The Indian Fertiliser Industry comprises of several ammonia and urea plants. The major process hazards associated with the manufacture of ammonia / urea include high pressures and temperatures, cryogenic hazards, corrosion, erosion, runaway reactions, large inventory of highly hazardous chemicals and flammable gases and chemicals. By managing these process hazards safely, disasters can be avoided. The article discusses the management of these major process hazards through asset integrity, maintaining process safety knowledge, managing changes safely and managing manpower attrition.